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By Robert Lev

Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the sizeable physique of easy technology and scientific info linked to adenomatous polyps of the colon, a lot of it encouraged by means of the belief that the majority colorectal carcinomas appear to come up in such polyps. This ebook strives to guage those information, with specific emphasis on their implications for administration of polyp-bearing matters. issues comprehensively explored comprise anatomy and histology of the traditional colon; pathologic features of adenomatous polyps, differential prognosis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic facts for the malignant capability of adenomatous polyps; and detection and administration, with unique cognizance to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.

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Extra resources for Adenomatous Polyps of the Colon: Pathobiological and Clinical Features

Sample text

Feczko PJ, Bernstein MA, Halpert RD, Ackerman LV (1984) Small colonic polyps: A reappraisal of their significance. Radiology 152: 30 1-303. 38 2. Pathology Fenoglio CM, Kaye 01, Pascal RR, Lane N (1977) Defining the precursor tissue of ordinary large bowel carcinoma: Implications for cancer prevention. Pathol Annu 12:87-116. Fenoglio CM, Richart RM, Kaye 01 (1975) Comparative electron microscopic features of normal, hyperplastic and adenomatous human colonic epithelium: Variations in surface architecture found by scanning electron microscopy.

The NPS pathologists also noted frequent disagreement of one 18 2. Pathology grade amplitude between them and the local pathologists submitting cases to that study (see M. , 1988). Brown et aI. (1985) found substantial inter- and intraobserver disagreement in the histological grading of dysplasia. Their morphometric analysis showed that (1) nuclearlcytoplasmic ratio and (2) variability (standard deviation) of nuclear area and height (but not absolute nuclear area and height) were of value in discriminating between the three grades of dysplasia, but it is unlikely that morphometry will be commonly used in diagnostic pathology.

B. , 1986). 3. 17 and Frontispiece, both appear in color preceding page 1). This is also called malignant polyp, whose behavior and management will be fully discussed in Chap. B. When malignant changes are confined to the glands and do not penetrate the epithelial basement membrane, the lesion is called severe dysplasia. Some pathologists also call this carcinoma in situ, but this term is avoided by other pathologists because of fear that unnecessary surgery may result from misinterpretation of such a report.

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